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Tackling progressive MS

Tackling Progressive MS is a priority. ECTRIMS had a meeting on this subject and they have done a special issue on this.

Here's a list of several papers on this subject.


The International Progressive MS alliance has made these open access so please read as they may be of interest.

Progressive MS trials: Lessons learned.
Mult Scler. 2017 Oct;23(12):1583-1592.

Advancing trial design in progressive multiple sclerosis.
Fox RJ, Chataway J.Mult Scler. 2017 Oct;23(12):1573-1578.

Advancing trial design in progressive multiple sclerosis.
Miller DH, Thompson AJ.Mult Scler. 2017 Oct;23(12):1571-1572.

Barro C, Leocani L, Leppert D, Comi G, Kappos L, Kuhle J.
Fluid biomarker and electrophysiological outcome measures for progressive MS trials.Mult Scler. 2017 Oct;23(12):1600-1613.

Wolinsky JS.Patient selection for trials.Mult Scler. 2017 Oct;23(12):1636-1641


Zaratin P, Comi G, Leppert D.'Progressive MS - macro views': The need for novel clinical trial paradigms to enable drug development for progressive MS.Mult Scler. 2017 Oct;23(12):1649-1655.


Moccia M, de Stefano N, Barkhof F.Imaging outcome measures for progressive multiple sclerosis trials.Mult Scler. 2017 Oct;23(12):1614-1626.


Lassmann H.Targets of therapy in progressive MS.Mult Scler. 2017 Oct;23(12):1593-1599

Ontaneda D, Cohen JA, Amato MP.Clinical outcome measures for progressive MS trials.Mult Scler. 2017 Oct;23(12):1627-1635.

First thing: What have I done to not get an invite :-(?

Maybe I am too frank!

What do these papers say:


There are three broad areas: systemic inflammation, compartmentalized inflammation and non-inflammatory neurodegeneration. They say "anti-inflammatory treatments are unlikely to be beneficial in this (progressive) stage of the disease, but neuroprotective and repair-inducing strategies may still be effective."


So maybe that's the problem. DrK would say "nonsense, wake-up and smell the roses people".  

They will say "this is why we won't support #ChariotMS, because it won't work". 

I say "Is there ambition to try and make a difference?" We think we need to deal with inflammation that occurs throughout MS, and likewise we need to protect and repair throughout MS

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